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Also known by its generic name Sibutramine, Meridia is mainly intended as an appetite suppressant in the treatment of obesity. Much like other appetite suppressant agents, the optimal effects of Meridia must also be combined with a healthy diet, routine exercise plan and behavioral changes. Although its mechanism of action is relatively different, it is related to amphetamines.
Meridia is a neurotransmitter reuptake inhibitor which reduces the reuptake of norepinephrine, serotonin, and dopamine that subsequently improves the levels of these substances in synaptic clefts therefore enhancing the feeling of satiety.
Sibutramine is available in 5 mg, 10 mg, and 15 mg capsules and taken orally. The initial recommended dosage is 10 mg of Meridia once daily with or without food. If weight loss is not enough, the dose can be titrated after four weeks to a maximum of 15 mg once a day. The changes in the patient’s heart rate and blood pressure levels must be considered when deciding on dose titration.
The most common adverse effects of Meridia include nausea, headaches, stomach aches, flushing, dizziness, constipation, joint or muscle pain and dry mouth. Meridia may also increase blood pressure levels so it is necessary for it to be monitored when using this drug. Several serious but rare adverse effects include paresthesia, sudden mental or mood changes and cardiac arrhythmia. It is important to be conscious of these adverse effects and to seek direct medical attention during its occurrence.
Several conditions are contraindications for the use of Meridia which include psychiatric conditions such as serious depression or bulimia nervosa, uncontrolled hypertension, allergies to the medication, patients under 18 years old, closed angle glaucoma, and pregnant or lactating women. Meridia should not be taken with other medications such as ergolines, selegiline, and triptans as it may cause severe adverse effects.